منابع مشابه
Thymus Cell Migration
THE PRECEDING STUDIES HAVE ESTABLISHED THE FOLLOWING POINTS: Intrathymic labeling of thymic lymphocytes provides an adequate marker system to detect the migration of thymus cells to peripheral lymphoid sites. In the newborn, this comprises a major portion of the total lymphocyte population in lymph nodes and spleen. In the adult, this migration is limited to specific portions of lymph nodes and...
متن کاملCell Migration from the Thymus to Other Lyinphoid Organs
T HE IMPORTANCE of the thymust in immunobiology was first shown in neonatally thymectomized rabbits and mice.3’25’48 Thymectomy after the neonatal period in these animals is not followed by any dramatic consequences. How the thymus exerts its influence upon the other lymphoid organs is not clear. There is evidence both for the existence of humoral factor( s ) of thymus origin10’38’43’53’54 and ...
متن کاملMultivectorial abnormal cell migration in the NOD mouse thymus.
We previously described a fibronectin/VLA-5-dependent impairment of NOD thymocyte migration, correlated with partial thymocyte arrest within thymic perivascular spaces. Yet, NOD thymocytes still emigrate, suggesting the involvement of other cell migration-related alterations. In this context, the aim of this work was to study the role of extracellular matrix ligands, alone or in combination wit...
متن کاملThymus Migration and Dendritic Cell Behavior in the Stromal Cell Networks Regulate Thymocyte
After entry into thymus, T cell progenitors migrate in the cortex and the medulla while completing their education. Recent reports have documented the dynamic and tortuous behavior of thymocytes. However, other than chemokines and/or segregated thymic substrates, the factors contributing to the dynamic patterns of thymocyte movement are poorly characterized. By combining con-focal and dynamic t...
متن کاملThymus Cell Maturation
Outer thymic cortical large lymphocytes were labeled by transcapsular administration of tritiated thymidine. By 2-4 days after labeling, small and medium labeled lymphocyte descendants were found throughout the cortex and in the medulla. The labeled cortical lymphocytes undergo pycnosis after parenteral administration of hydrocortisone 24 h previously, but their (labeled) medullary descendants ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1967
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.126.2.291